Tetrahedron

Solid phase β-lactams synthesis using the Staudinger reaction, monitored by 19 F NMR spectroscopy

I Le Roy, D Mouysset, S Mignani, M Vuilhorgne…

Index: Le Roy, Isabelle; Mouysset, Dominique; Mignani, Serge; Vuilhorgne, Marc; Stella, Lucien Tetrahedron, 2003 , vol. 59, # 21 p. 3719 - 3727

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Citation Number: 28

Abstract

We report the use of 19F NMR as a simple means to monitor reactions on a solid phase. Multi-step sequences including protection, coupling, deprotection, condensation, cycloaddition and cleavage steps are described in the case of multicomponent reactions involving fluorinated α-aminoesters, aldehydes and acid chlorides.