2-[(3-Methoxyphenylethyl) phenoxy]-based ABCB1 inhibitors: Effect of different basic side-chains on their biological properties

…, R Perrone, S Rapposelli, M Digiacomo…

Index: Colabufo, Nicola Antonio; Berardi, Francesco; Perrone, Roberto; Rapposelli, Simona; Digiacomo, Maria; Vanni, Michael; Balsamo, Aldo Journal of Medicinal Chemistry, 2008 , vol. 51, # 23 p. 7602 - 7613

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Citation Number: 15

Abstract

Recently, 2-[(3-methoxyphenylethyl) phenoxy]-moiety has been selected for the design and synthesis of new small ABCB1 inhibitors. In the present paper, this moiety has been linked through a spacer of 2− 5 carbon atoms to the nitrogen of three different basic nuclei such as:(i) N-4-arylpiperazine,(ii) N-4-methylpiperazine, and (iii) 6, 7- dimethoxytetrahydroisoquinoline. The results demonstrated that all the selected basic ...