A microwave improvement in the synthesis of the quinazoline scaffold

A Chilin, G Marzaro, S Zanatta, A Guiotto

Index: Chilin, Adriana; Marzaro, Giovanni; Zanatta, Samuele; Guiotto, Adriano Tetrahedron Letters, 2007 , vol. 48, # 18 p. 3229 - 3231

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Citation Number: 24

Abstract

A rapid and efficient microwave-assisted protocol is described that greatly improves a recent synthetic method developed for quinazoline synthesis. The synthetic protocol is based on the use of cycles of microwave irradiation. The optimization process is reported and the experimental results are compared with those of the conventional synthetic route.