Oxidation of thymines and uracils with sodium peroxodisulfate

T Itahara, R Ebihara, Y Fujii, M Tada

Index: Itahara, Toshio; Ebihara, Reiko; Fujii, Yukiko; Tada, Miki Chemistry Letters, 1986 , p. 1319 - 1322

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Citation Number: 9

Abstract

Reaction of thymines with Na 2 S 2 O 8 in water resulted in selective oxidation of the methyl group at 5-position of thymines. Oxidation of thymines with Na 2 S 2 O 8 in hydrochloric acid gave 5-chloro-6-hydroxy-5, 6-dihydrothymines and in acetic acid containing NaCl gave 6- acetoxy-5-chloro-5, 6-dihydrothymines which were converted to 6-alkoxy-5-chloro-5, 6- dihydrothymines with alcohols. The reaction of uracils also gave similar products together ...