Synthesis of imidazothiazole–chalcone derivatives as anticancer and apoptosis inducing agents

…, S Pushpavalli, D Pal, M Pal??Bhadra

Index: Kamal, Ahmed; Dastagiri; Ramaiah, M. Janaki; Reddy, J. Surendranadha; Bharathi, E. Vijaya; Srinivas, Chatla; Pushpavalli; Pal, Dhananjaya; Pal-Bhadra, Manika ChemMedChem, 2010 , vol. 5, # 11 p. 1937 - 1947

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Citation Number: 34

Abstract

Abstract A new class of imidazo [2, 1-b] thiazole chalcone derivatives were synthesized and evaluated for their anticancer activity. These chalcone derivatives show promising activity, with log GI 50 values ranging from− 7.51 to− 4.00. The detailed biological aspects of these derivatives toward the MCF-7 cell line were studied. Interestingly, these chalcone derivatives induced G 0/G 1-phase cell-cycle arrest, down-regulation of G 1-phase cell-cycle ...