Selective non-nucleoside HIV-1 reverse transcriptase inhibitors. New 2, 3-dihydrothiazolo [2, 3-a] isoindol-5 (9bH)-ones and related compounds with anti-HIV-1 …
A Mertens, H Zilch, B Koenig, W Schaefer…
Index: Mertens, Alfred; Zilch, Harald; Koenig, Bernhard; Schaefer, Wolfgang; Poll, Thomas; et al. Journal of Medicinal Chemistry, 1993 , vol. 36, # 17 p. 2526 - 2535
Full Text: HTML
Citation Number: 132
Abstract
Introduction The human immune deficiency virus 1 is the causative agent of the acquired immune deficiency syndrome (AIDS). 2 The epidemic spread of this disease is dramatically increased by recent estimates of the WHO. 3 So far, the only approved drugs for the therapy of HIV-1 infection are 3'-azidothymidine (AZT, Zid~ vudine)~ and recently 2', 3'- didesoxyinoeine (ddI, Didano~ ine)~ and 2', 3'-didesoxycytidine (ddC, Zalcitabine). 6 ...
Related Articles:
[Asano, Yasutomi; Kitamura, Shuji; Ohra, Taiichi; Aso, Kazuyoshi; Igata, Hideki; Tamura, Tomoko; Kawamoto, Tomohiro; Tanaka, Toshimasa; Sogabe, Satoshi; Matsumoto, Shin-ichi; Yamaguchi, Masashi; Kimura, Hiroyuki; Itoh, Fumio Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 8 p. 4715 - 4732]
[Aeberli,P. et al. Journal of Medicinal Chemistry, 1975 , vol. 18, # 2 p. 177 - 182]
[Aeberli,P. et al. Journal of Medicinal Chemistry, 1975 , vol. 18, # 2 p. 177 - 182]
[Aeberli,P. et al. Journal of Medicinal Chemistry, 1975 , vol. 18, # 2 p. 177 - 182]