Design of low molecular weight hematoregulatory agents from the structure-activity relationship of a dimeric pentapeptide

…, M Husbyn, M Engebretsen, M Hartmann…

Index: Cuthbertson, Alan S.; Husbyn, Mette; Engebretsen, May; Hartmann, Michael; Lange, Meinolf; Sandosham, Jessie; Fischer, Peter M.; Fjerdingstad, Hege; Lovhaug, Dagfinn Journal of Medicinal Chemistry, 1997 , vol. 40, # 18 p. 2876 - 2882

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Citation Number: 4

Abstract

We report herein, a new class of simple hematoregulatory semipeptides, formally derived from the cystine-dimerized peptide pGlu-Glu-Asp-Cys-Lys-OH, where the disulfide bond has been replaced by an isosteric dicarba bridge. The structure-activity relationship (SAR) of a series of analogues incorporating replacements at positions 1 and 2 of peptide 1 led to the design of active conformationally constrained cyclic peptides (12, 13). Ring closure was ...