Structure–activity relationship of thiopyrimidines as mGluR5 antagonists

LG Hammerland, M Johansson, J Malmström…

Index: Hammerland, Lance G.; Johansson, Martin; Malmstroem, Jonas; Mattsson, Jan P.; Minidis, Alexander B. E.; Nilsson, Karolina; Peterson, Alecia; Wensbo, David; Wallberg, Andreas; Oesterlund, Krister Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 9 p. 2467 - 2469

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Citation Number: 12

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Structure–activity relationship investigations of the thiopyrimidine (1), an HTS hit with micromolar activity as a metabotropic glutamate receptor 5 (mGluR5) antagonist, led to compounds with sub-micromolar activity. ... Structure–activity relationship investigation of thiopyrimidines ...