Orally active cephalosporins and penicillins

EHW Böhme, RE Bambury, RJ Baumann…

Index: Boehme, E. H. W.; Bambury, R. E.; Baumann, R. J.; Erickson, R. C.; Harrison, B. L.; et al. Journal of Medicinal Chemistry, 1980 , vol. 23, # 4 p. 405 - 412

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Citation Number: 6

Abstract

To obtain the compounds listed in Tables I and 11, the above prepared acids were first coupled to the cephalosporin nucleus. Deprotection then gave the desired structures. One or more of the following methods of Scheme IV were used to prepare molecules 12 through 27. Synthesis of 28 was achieved according to Scheme V.