Transkarbams as transdermal permeation enhancers: effects of ester position and ammonium carbamate formation

M Novotný, A Hrabálek, B Janůšová, J Novotný…

Index: Novotny, Michal; Hrabalek, Alexandr; Janusova, Barbora; Novotny, Jakub; Vavrova, Katerina Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 9 p. 2726 - 2728

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Citation Number: 7

Abstract

Transkarbam 12, an ammonium carbamate formed by the reaction of dodecyl 6- aminohexanoate with carbon dioxide, is a highly active, broad-spectrum, nontoxic, and nonirritant transdermal permeation enhancer. It probably acts by a dual mechanism: a part of its activity is associated with the carbamic acid salt and/or its decomposition in the acidic stratum corneum. The ammonium ester thereby released is an active enhancer species as ...