Molecules

Hexachlorocyclotriphosphazene (HCCP)-mediated direct formation of thioethers and ethers from quinazolin-4 (3H)-ones

B Hu, X Zhang, L Sheng, M Guo, Z Shen, X Hu, N Sun…

Index: Hu, Baoxiang; Zhang, Xiaochu; Sheng, Lili; Guo, Ming; Shen, Zhenlu; Hu, Xinquan; Sun, Nan; Mo, Weimin Molecules, 2013 , vol. 18, # 5 p. 5580 - 5593

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Citation Number: 3

Abstract

Abstract: A hexachlorocyclotriphosphazene (HCCP)-mediated direct formation of quinazoline (thio) ethers from quinazolin-4 (3 H)-ones has been developed. Treatment of quinazolin-4 (3 H)-ones with HCCP, diisopropylethylamine (DIPEA), and thiophenols resulted in formation of the corresponding 4-arylthioquinazoline derivatives in moderate to excellent yields. This method has also been utilized to prepare 4-aryloxyquinazoline and ...