Fluorine-containing heterocycles: XIX. Synthesis of fluorine-containing quinazolin-4-ones from 3, 1-benzoxazin-4-ones

…, EV Nosova, GN Lipunova, AV Golovchenko…

Index: Laeva; Nosova; Lipunova; Golovchenko; Adonin; Parmon; Charushin Russian Journal of Organic Chemistry, 2009 , vol. 45, # 6 p. 913 - 920

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Citation Number: 13

Abstract

Abstract Reactions of fluorine-containing 3, 1-benzoxazin-4-ones with ammonium acetate, hydrazine, and heteroaromatic amines gave new 3 H-, 3-amino-, and 3-hetarylquinazolin-4- ones, respectively. Differences in the conditions of formation of benzoxazinones from anthranilic acids with different fluorination patterns and in the reactions of fluorinated 3, 1- benzoxazinones with nitrogen-centered nucleophiles were revealed.