Electrophilic N-amination of two quinazoline-2, 4-diones using substituted (nitrophenyl) hydroxylamines

DC Boyles, TT Curran, RV Parlett IV…

Index: Boyles, David C.; Curran, Timothy T.; Parlett IV, Roger V.; Davis, Mark; Mauro, Frank Organic Process Research and Development, 2002 , vol. 6, # 3 p. 230 - 233

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Citation Number: 21

Abstract

The preparation of a few (nitrophenyl) hydroxylamines and reaction with two quinazoline-2, 4-diones is described. The electrophilic aminating agents were assessed in terms of yield for the N-amination of two quinazoline-2, 4-diones and safety considerations for rapid scale-up. For the amination of the described system, the best yield and the highest onset temperature were found in the same aminating agent, specifically,(4-nitrophenyl) hydroxylamine.

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