Syntheses based on β-phenylethylamines V. Synthesis and preliminary pharmacological screening of some phenylalkylamines and N-benzyltetrahydroisoquinolines

…, MS Yunusov, GA Suleimanova, N Tulyaganov

Index: Vinogradova, V. I.; Golodnyuk, T. I.; Yunusov, M. S.; Suleimanova, G. A.; Tulyaganov, N. Chemistry of Natural Compounds, 1993 , vol. 29, # 5 p. 654 - 657 Khimiya Prirodnykh Soedinenii, 1993 , # 5 p. 736 - 740

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Abstract

Synthetic chemistry provides an approach to the the question of creating new drugs by modifying the molecular structures of biologically active compounds, which will permit the creation of more effective agents for treatment and prophylaxis combining high activity and low toxicity. There is information in the literature on the synthesis of a series of N-benzyltetrahydroisoquinolines -- analogues of the alkaloids sendaverine, corgoine, intebrimine -- and on the detection of ...