Tetrahedron letters

Aromatic organozinc reagents as nucleophiles in the α-arylation of piperidine and tetrahydropyran

E Le Gall, C Gosmini, M Troupel

Index: Le Gall, Erwan; Gosmini, Corinne; Troupel, Michel Tetrahedron Letters, 2006 , vol. 47, # 4 p. 455 - 458

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Citation Number: 7

Abstract

The arylation at the α-position of piperidine derivatives is achieved in good yield using aromatic organozinc reagents and either 2-methoxylated or α-cyanated piperidine. Oxygen- containing heterocycles such as 2-methoxy-tetrahydropyran reacts in a same manner to yield efficiently 2-arylated tetrahydropyran.

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