Enantioselective Synthesis of (−)??CP??55940 via Ruthenium??Catalyzed Asymmetric Hydrogenation of Ketones

LJ Cheng, JH Xie, LX Wang…

Index: Cheng, Li-Jie; Xie, Jian-Hua; Wang, Li-Xin; Zhou, Qi-Lin Advanced Synthesis and Catalysis, 2012 , vol. 354, # 6 p. 1105 - 1113

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Citation Number: 8

Abstract

Abstract A new and efficient catalytic asymmetric synthesis of the potent cannabinoid receptor agonist (−)-CP-55940 has been developed by using ruthenium-catalyzed asymmetric hydrogenation of racemic α-aryl ketones via dynamic kinetic resolution (DKR) as a key step. With RuCl 2-SDPs/diamine [SDPs= 7, 7′-bis (diarylphophino)-1, 1′- spirobiindane] catalysts the asymmetric hydrogenation of racemic α-arylcyclohexanones ...