Structure-activity relationships in platelet-activating factor. 12. Synthesis and biological evaluation of platelet-activating factor antagonists with anti-HIV-1 activity

…, N Dereuddre-Bosquet, J Huet…

Index: Serradji, Nawal; Bensaid, Okkacha; Martin, Marc; Kan, Erwan; Dereuddre-Bosquet, Nathalie; Redeuilh, Catherine; Huet, Jack; Heymans, Francoise; Lamouri, Aazdine; Clayette, Pascal; Dong, Chang Zhi; Dormont, Dominique; Godfroid, Jean-Jacques Journal of Medicinal Chemistry, 2000 , vol. 43, # 11 p. 2149 - 2154

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Citation Number: 19

Abstract

The HIV-1 central nervous system infection leads to the onset of neurological impairments called AIDS dementia complex (ADC). PAF plays an important role in this pathology, as it is an HIV-1-induced neurotoxin produced by infected or activated macrophages and microglia, in the brain. We previously reported that PAF-antagonists bearing a trisubstituted piperazine presented in vitro anti-HIV-1 activity in human macrophages. To improve the ...