The Journal of Organic Chemistry

Synthesis of 6-substituted 7H-pyrido [4, 3-c] carbazoles

SP Modi, AH Zayed, S Archer

Index: Modi, Sandeep P.; Zayed, Abdel-Hadi; Archer, Sydney Journal of Organic Chemistry, 1989 , vol. 54, # 13 p. 3084 - 3087

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Citation Number: 19

Abstract

Oxidative photocyclization furnished the 6-carbomethoxy-7H-pyrido [4, 3-c] carbazoles 18 and 24. Reduction with lithium aluminum hydride gave the carbinols 19 and 23, which when treated with methyl isocyanate gave the corresponding N-methylcarbamates 20 and 26, which are potential antitumor agents. Manganese dioxide oxidation of 19 and 25 furnished the aldehydes 21 and 27. Treatment with methylenetriphenylphosphorane gave olefins 22 ...