Synthesis of 4-, 5-, 11-, and 12-chloromethylbenzo [a] pyrene

AA Leon, GH Daub, DL VanderJagt

Index: Leon, Alberto A.; Daub, Guido H.; VanderJagt, David L. Journal of Organic Chemistry, 1985 , vol. 50, # 5 p. 553 - 556

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Citation Number: 2

Abstract

Serles d: Ar= 12-benz [a] anthracenyl Serles c: Ar= 5-chrysenyl because it would provide formyl esters that could be cyclized to provide functionalized B [a] P's. This approach proved successful, allowing the isolation of formyl esters 4a-d. At this point, a mild cyclizing agent was necessary because when 4a-d were allowed to react under standard acidic cyclization conditions (polyphosphoric acid, sulphuric acid, HF, etc.) low yields of product and large ...