. alpha.-Adrenergic agents. 2. Synthesis and. alpha. 1-agonist activity of 2-aminotetralins

…, RF Hall, JP Hieble, RG Pendleton

Index: DeMarinis, R. M.; Shah, D. H.; Hall, R. F.; Hieble, J. P.; Pendleton, R. G. Journal of Medicinal Chemistry, 1982 , vol. 25, # 2 p. 136 - 141

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Citation Number: 24

Abstract

OH 1 (norepinephrine) 2 (methoxamine) 3 (phenylephrine) about equal potency on both pre- and postjunctional a receptors (ECm on al= 1.5 XM). Other agents, such as methoxamine (2) or phenylephrine (3), are more selective for the postjunctional al receptor. 2 In a previous paper in this series2 we described the synthesis and al-adrenergic potency of a series of structurally diverse compounds related to the a,-agonist methoxamine. From among these ...