Hydrophosphinylation of unactivated terminal alkenes catalyzed by nickel chloride

S Ortial, HC Fisher, JL Montchamp

Index: Ortial, Stephanie; Fisher, Henry C.; Montchamp, Jean-Luc Journal of Organic Chemistry, 2013 , vol. 78, # 13 p. 6599 - 6608

Full Text: HTML

Citation Number: 23

Abstract

The room-temperature hydrophosphinylation of unactivated monosubstituted alkenes using phosphinates (ROP (O) H2) and catalytic NiCl2 in the presence of dppe is described. The method is competitive with prior palladium-catalyzed reactions and uses a much cheaper catalyst and simple conditions. The scope of the reaction is quite broad in terms of unactivated terminal olefins, proceeds at room temperature, often avoids chromatographic ...