Practical synthesis of (R)-(+)-6-(1, 4-dimethoxy-3-methyl-2-naphthyl)-6-(4-hydroxyphenyl) hexanoic acid: a key intermediate for a therapeutic drug for …

…, T Ikemoto, T Yamano, Y Mizuno, K Tomimatsu

Index: Ito, Tatsuya; Ikemoto, Tomomi; Yamano, Toru; Mizuno, Yukio; Tomimatsu, Kiminori Tetrahedron Asymmetry, 2003 , vol. 14, # 22 p. 3525 - 3531

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Citation Number: 14

Abstract

A practical method for the preparation of (R)-(+)-6-(1, 4-dimethoxy-3-methyl-2-naphthyl)-6-(4- hydroxyphenyl) hexanoic acid (R)-2, a key intermediate for a therapeutic drug for neurodegenerative diseases, has been developed. rac-Methyl 6-(1, 4-dimethoxy-3-methyl-2- naphthyl)-6-(4-(propionyloxy) phenyl) hexanoate rac-9b was synthesized from 2- methylnaphthoquinone in seven steps. An optically active ester (R)-9b was readily ...

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