The Journal of organic chemistry

Synthesis of 1-deoxy-D-xylulose and 1-deoxy-D-xylulose-5-phosphate

BSJ Blagg, CD Poulter

Index: Blagg, Brian S. J.; Poulter, C. Dale Journal of Organic Chemistry, 1999 , vol. 64, # 5 p. 1508 - 1511

Full Text: HTML

Citation Number: 39

Abstract

1-Deoxy-d-xylulose (4) and the corresponding 5-phosphate (5) are substrates for the first pathway-specific enzymes in the biosynthesis of thiamine diphosphate (vitamin B1), pyridoxol phosphate (vitamin B6), and the nonmevalonate family of isoprenoid compounds recently discovered in bacteria and plant chloroplasts. Both 4 and 5 were synthesized from commercially available (-)-2, 3-O-isopropylidene-d-threitol (10). The protected tetraol was ...

Related Articles:

A chemo-enzymatic cascade for the one-pot synthesis of 1-deoxy-d-xylulose 5-phosphate and 1-deoxy-d-xylulose

[Dai, Shao-Bo; Liao, Juan; Tian, Jie; Li, Heng; Gao, Wen-Yun Tetrahedron Letters, 2012 , vol. 53, # 36 p. 4809 - 4812]

Chemical and enzymatic synthesis of 1-deoxy-D-xylulose-5-phosphate

[Taylor, Sean V.; Vu, Long D.; Begley, Tadhg P. Journal of Organic Chemistry, 1998 , vol. 63, # 7 p. 2375 - 2377]

Optimized enzymatic preparation of 1-deoxy-d-xylulose 5-phosphate

[Zhou, Yue-Fei; Cui, Zhe; Li, Heng; Tian, Jie; Gao, Wen-Yun Bioorganic Chemistry, 2010 , vol. 38, # 3 p. 120 - 123]

Revealing substrate promiscuity of 1-deoxy-D-xylulose 5-phosphate synthase

[Brammer, Leighanne A.; Meyers, Caren Freel Organic Letters, 2009 , vol. 11, # 20 p. 4748 - 4751]

An Improved Preparation of D??Glyceraldehyde 3??Phosphate and Its Use in the Synthesis of 1??Deoxy??D??xylulose 5??Phosphate

[Li, Heng; Tian, Jie; Wang, Hui; Yang, Shao-Qing; Gao, Wen-Yun Helvetica Chimica Acta, 2010 , vol. 93, # 9 p. 1745 - 1750]

More Articles...