Synthesis and anticancer activities of some novel 2-(benzo [d] thiazol-2-yl)-8-substituted-2H-pyrazolo [4, 3-c] quinolin-3 (5H)-ones

…, C Pessoa, LV Costa-Lotufo, MO de Moraes…

Index: Reis, Raisa Da R.; Azevedo, Elisa C.; De Souza, Maria Cecilia B.V.; Ferreira, Vitor Francisco; Montenegro, Raquel C.; Araujo, Ana Jersia; Pessoa, Claudia; Costa-Lotufo, Leticia V.; De Moraes, Manoel O.; Filho, Jose D.B.M.; De Souza, Alessandra M.T.; De Carvalho, Natasha C.; Castro, Helena C.; Rodrigues, Carlos R.; Vasconcelos, Thatyana R.A. European Journal of Medicinal Chemistry, 2011 , vol. 46, # 4 p. 1448 - 1452

Full Text: HTML

Citation Number: 3

Abstract

A series of 2-(benzo [d] thiazol-2-yl)-8-substituted-2H-pyrazolo [4, 3-c] quinolin-3 (5H)-ones (3a–g) have been synthesized and evaluated for their in vitro antiproliferative activities against four human cancer cell lines: MDA-MB-435 (breast), HL-60 (leukemia), HCT-8 (colon) and SF-295 (central nervous system). The results showed that the compounds 3b (2- (benzo [d] thiazol-2-yl)-8-methyl-2H-pyrazolo [4, 3-c] quinolin-3 (5H)-one) and 3c (2-( ...