Design and synthesis of 3, 3-piperidine hydroxamate analogs as selective TACE inhibitors

HG Lombart, E Feyfant, D Joseph-McCarthy…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 15 p. 4333 - 4337

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Citation Number: 14

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... b Chemical and Screening Sciences, Wyeth Research, 401 N. Middletown Road, Pearl River, NY 10965, USA; c Inflammation, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA. ...

Synthesis and structure-activity relationships of β-and α-piperidine sulfone hydroxamic acid matrix metalloproteinase inhibitors with oral antitumor efficacy

[Becker, Daniel P.; Villamil, Clara I.; Barta, Thomas E.; Bedell, Louis J.; Boehm, Terri L.; DeCrescenzo, Gary A.; Freskos, John N.; Getman, Daniel P.; Hockerman, Susan; Heintz, Robert; Howard, Susan Carol; Li, Madeleine H.; McDonald, Joseph J.; Carron, Chris P.; Funckes-Shippy, Chris L.; Mehta, Pramod P.; Munie, Grace E.; Swearingen, Craig A. Journal of Medicinal Chemistry, 2005 , vol. 48, # 21 p. 6713 - 6730]

Design and synthesis of 3, 3-piperidine hydroxamate analogs as selective TACE inhibitors

Abstract

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