Peptido sulfonyl fluorides as new powerful proteasome inhibitors

…, BI Florea, M Groll, HS Overkleeft…

Index: Verdoes, Martijn; Florea, Bogdan I.; Van Der Linden, Wouter A.; Renou, Didier; Van Den Nieuwendijk, Adrianus M. C. H.; Van Der Marel, Gijs A.; Overkleeft, Herman S. Organic and Biomolecular Chemistry, 2007 , vol. 5, # 9 p. 1416 - 1426

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Citation Number: 19

Abstract

A new class of potent proteasome inhibitors is described, of which the members contain an amino acid inspired sulfonyl fluoride as the electrophilic trap. In total, 24 peptido sulfonyl fluoride inhibitors have been designed and synthesized, which were inspired by the