Efficient syntheses of korupensamines A, B and michellamine B by asymmetric Suzuki-Miyaura coupling reactions

…, W Fu, G Liu, CH Senanayake, W Tang

Index: Xu, Guangqing; Fu, Wenzhen; Liu, Guodu; Senanayake, Chris H.; Tang, Wenjun Journal of the American Chemical Society, 2014 , vol. 136, # 2 p. 570 - 573

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Citation Number: 65

Abstract

Efficient asymmetric Suzuki-Miyaura coupling reactions are employed for the first time in total syntheses of chiral biaryl natural products korupensamine A and B in combination with an effective diastereoselective hydrogenation, allowing ultimately a concise and stereoselective synthesis of michellamine B. Chiral monophosphorus ligands L1–3 are effective for the syntheses of a series of functionalized chiral biaryls by asymmetric Suzuki- ...