Synthesis of viscumamide and its analogs

A Sakurai, Y Okumura

Index: Sakurai,A.; Okumura,Y. Bulletin of the Chemical Society of Japan, 1979 , vol. 52, p. 540 - 543

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Citation Number: 11

Abstract

Viscumamide, cyclo (–L-Leu–L-Ile–L-Leu–L-Ile–L-Leu–)(1a) and its three analogs, cyclo (–L- Leu–L-Leu–L-Leu–L-Leu–L-Leu–), cyclo (–L-Leu-L-Ile-L-Leu–L-Leu–L-Leu–), and cyclo (–L- Ile–L-Ile–L-549. tex Leu–L-Leu–L-Leu–) were synthesized by the N-hydroxysuccinimide ester method. The yields in the cyclization step were low due to a strong intermolecular association even at high dilution, which causes cyclodimerization and other ...