Solid phase synthesis of benzothiazolyl compounds

S Mourtas, D Gatos, K Barlos

Index: Mourtas, Spyros; Gatos, Dimitrios; Barlos, Kleomenis Tetrahedron Letters, 2001 , vol. 42, # 11 p. 2201 - 2204

Full Text: HTML

Citation Number: 47

Abstract

2-Aminobenzenethiol, bound through its thiol function to the 2-chlorotrityl (Clt)-, trityl (Trt)-, 4- methyltrityl (Mtt)-and 4-methoxytrityl (Mmt)-resins, was acylated at the amino-function by aliphatic and aromatic acids. The obtained 2-N-acyl-aminobenzenethiols were cleaved from the resin by treatment with trifluoroacetic acid solutions in dichloromethane. The 2-N-acyl- aminobenzenethiols released from the resin were cyclised to the corresponding 2- ...