The Journal of Organic Chemistry

A chiral stationary phase for the facile resolution of amino acids, amino alcohols and amines as the N-3, 5-dinitrobenzoyl derivatives

WH Pirkle, MH Hyun

Index: Pirkle, William H.; Hyun, Myung Ho Journal of Organic Chemistry, 1984 , vol. 49, # 17 p. 3043 - 3046

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Citation Number: 119

Abstract

A chiral stationary phase derived from a-(6, 7-dimethyl-l-naphthyl) isobutylamine is quite effective for the liquid chromatographic separation of the enantiomers of the N-3, 5- dinitrobenzoyl derivatives of a-amino acids, their esters and amides, amino alcohols, and amines. For example, the chromatographic separation factor for the enantiomers of derivatized methyl phenylalanate is 4.73, the band shapes are excellent, and the ...