Synthesis and biological evaluation of 7-chloro-1-trideuteriomethyl-5-phenyl-1H-1, 5-benzodiazepine-2, 4 (3H, 5H)-dione (clobazam-d 3)

JH Poupaert, P Guiot, P Jacqmin, P Dumont

Index: Poupaert, Jacques H.; Guiot, Pierre; Jacqmin, Philippe; Dumont, Pierre European Journal of Medicinal Chemistry, 1988 , vol. 23, p. 417 - 420

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Citation Number: 2

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Clobazam-d 3 has been prepared by treatment of norclobazam sodium salt with trideuteriomethyl iodide. Clobazam-d 3 has a pharmacological profile rather similar to that of clobazam. It differs by its longer duration of anti-epileptic action. ... Le clobazam-d 3 a été synthétisé par ...