Structure–Activity Relationships of Targeted RuII (η6-p-Cymene) Anticancer Complexes with Flavonol-Derived Ligands

A Kurzwernhart, W Kandioller, S Bächler…

Index: Kurzwernhart, Andrea; Kandioller, Wolfgang; Bartel, Caroline; Baechler, Simone; Trondl, Robert; Muehlgassner, Gerhard; Jakupec, Michael A.; Arion, Vladimir B.; Marko, Doris; Keppler, Bernhard K.; Hartinger, Christian G. Chemical Communications, 2012 , vol. 48, # 40 p. 4839 - 4841

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Citation Number: 51

Abstract

RuII (arene) complexes have been shown to be promising anticancer agents, capable of overcoming major drawbacks of currently used chemotherapeutics. We have synthesized RuII (η6-arene) compounds carrying bioactive flavonol ligands with the aim to obtain multitargeted anticancer agents. To validate this concept, studies on the mode of action of the complexes were conducted which indicated that they form covalent bonds to DNA, ...