Fluorous derivatives of (1R, 2R)-diaminocyclohexane as chiral ligands for metal-catalyzed asymmetric reactions

J Bayardon, D Sinou, O Holczknecht, L Mercs…

Index: Bayardon, Jerome; Sinou, Denis; Holczknecht, Orsolya; Mercs, Laszlo; Pozzi, Gianluca Tetrahedron Asymmetry, 2005 , vol. 16, # 13 p. 2319 - 2327

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Citation Number: 25

Abstract

Perfluoroalkyl-substituted, enantiopure diamines derived from (1R, 2R)-diaminocyclohexane were conveniently prepared from readily available precursors. In situ generated metal complexes of these ligands were tested as chiral catalysts in three standard asymmetric reactions (cyclopropanation of styrene, hydrogen transfer reduction of acetophenone, and allylic alkylation of 1, 3-diphenyl-2-propenyl acetate) affording enantioselectivities of up to ...

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