Synthesis and effects of some novel tetrahydronaphthalene derivatives on proliferation and nitric oxide production in lipopolysaccharide activated Raw 264.7 …

…, AZ Karabay, Z Buyukbingol, E Buyukbingol

Index: Gurkan, A. Selen; Karabay, Arzu Z.; Buyukbingol, Zeliha; Buyukbingol, Erdem European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 468 - 479

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Citation Number: 3

Abstract

In this study, novel N-(3, 5, 5, 8, 8-pentamethyl-5, 6, 7, 8-tetrahydronaphthalene-2-yl)- carboxamide (6–15) and 5, 5, 8, 8-tetramethyl-5, 6, 7, 8-tetrahydronaphthalene-2- carboxamide (16–32) derivatives were synthesized and their in vitro effects at 5μM and 50μM concentrations on proliferation and nitric oxide (NO) production in lipopolysaccharide (LPS) activated RAW 264.7 macrophage cells were determined. Compounds 12, 17, 24 ...

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