European journal of medicinal chemistry

Novel tricyclic spiropiperidines. Synthesis and adrenergic activity of spiro [1, 3-benzodioxolopiperidines] and spiro [1, 3-benzodioxanepiperidines]

MD Pujol, G Rosell, G Guillaumet

Index: Pujol; Rosell; Guillaumet European Journal of Medicinal Chemistry, 1996 , vol. 31, # 11 p. 889 - 894

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Citation Number: 4

Abstract

The synthesis of new series of spiropiperidines is reported. Some of these compounds showed interesting adrenergic activity. The biological activities of the new compounds were evaluated on-guinea pig atria (β1), guinea-pig trachea (β2) and rat vas deferens (α). Compounds 6a, 6c and 6f showed activity comparable to propranolol, in spite of being tertiary amines.