Tetrahedron Letters

An efficient synthetic route for quinazolinyl 4-thiazolidinones

JR Mali, UR Pratap, PD Netankar, RA Mane

Index: Mali, Jyotirling R.; Pratap, Umesh R.; Netankar, Prashant D.; Mane, Ramrao A. Tetrahedron Letters, 2009 , vol. 50, # 35 p. 5025 - 5027

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Citation Number: 28

Abstract

An efficient solvent-free cyclocondensation route for condensing mercaptoacetic acid with quinazolinyl-substituted azomethines has been developed using silica chloride as a catalyst for obtaining heteryl-substituted 4-thiazolidinones. The route is found to be rapid, relatively economical, and eco-friendly. The precursors, quinazolinyl azomethines have been obtained in multisteps starting from quinazolinone.