Development and evaluation of a pharmacophore model for inhibitors of aldosterone synthase (CYP11B2)

S Ulmschneider, M Negri, M Voets…

Index: Ulmschneider, Sarah; Negri, Matthias; Voets, Marieke; Hartmann, Rolf W. Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 1 p. 25 - 30

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Citation Number: 23

Abstract

Recently, we proposed inhibition of aldosterone synthase (CYP11B2) as a novel strategy for the treatment of congestive heart failure and myocardial fibrosis and synthesized a large number of inhibitors. In this work, a pharmacophore model for CYP11B2 inhibitors was developed by superimposition of active and non-active compounds. This model was confirmed by the synthesis of two pyridyl substituted acenaphthene derivatives (A, B). This ...