Syntheses of substituted 1??methyl??2??(1, 3, 4??thiadiazol??2??yl)??4??nitropyrroles and 1??methyl??2??(1, 3, 4??oxadiazol??2??yl)??4??nitropyrroles

…, A Fooladi, A Foroumadi, A Shafiee

Index: Firoozi; Javidnia; Kamali; Fooladi; Foroumadi; Shafiee Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 1 p. 123 - 128

Full Text: HTML

Citation Number: 21

Abstract

Abstract Starting from readily available ethyl-4-nitropyrrole-2-carboxylate (1), substituted 1- methyl-2-(1, 3, 4-thiadiazol-2-yl)-4-nitropyrroles and 1-methyl-2-(1, 3, 4-oxadiazol-2-yl)-4- nitropyrroles were prepared. The reaction of 1 with diazomethane gave ethyl 1-methyl-4- nitropyrrole-2-carboxylate (2). Reaction of compound 2 with hydrazine hydrate afforded the corresponding hydrazide 3. The reaction of 3 with formic acid yielded 1-(1-methyl-4- ...