Synthesis and glucose-6-phosphatase inhibitory activity of (thiouriedo) alkanoic acid esters
D Sil, BK Tripathi, AK Srivastava, VJ Ram
Index: Farhanullah; Sil, Diptesh; Tripathi, Brajendra K.; Srivastava, Arvind K.; Ram, Vishnu Ji Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 10 p. 2571 - 2574
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Abstract
A series of (3-pyridin-2-yl-thiouriedo) alkanoic acid esters (5a–j) have been synthesized by the reaction of pyridin-2-yl-dithiocarbamic acid methyl ester (2) and amino acid esters (4). Most of the synthesized compounds have been evaluated against glucose-6-phosphatase enzyme but only four compounds (5g–j) displayed significant inhibitory activity of the enzyme.
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