A new method for the preparation of 1, 2-benzisoxazole-3-carboxaldehyde

…, SP Panchgalle, KK Mahakal…

Index: Kalkote, Uttam R.; Panchgalle, Sharad P.; Mahakal, Kumodini K.; Choudhary, Suman M.; Chavan, Subhash P. Journal of Chemical Research, 2005 , # 2 p. 99 - 100

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Abstract

We made various attempts to oxidise 3-methyl-1, 2-benzisoxazole (2) to the aldehyde (1) in one step (Table 1); unfortunately, all attempts were unsuccessful. It was then planned to convert 3-methyl-1,2-benzisoxazole (2) into 3-bromomethyl-1,2-benzisoxazole (3a) followed by oxidation to 1,2-benzisoxazole-3-carboxaldehyde (1). Attempts to convert 3-bromomethyl-1,2-benzisoxazole (3a) into 1,2-benzisoxazole-3-carboxaldehyde (1), and to hydrolyse 3-bromo methyl-1,2- ...