Synthesis, binding affinity, and molecular docking analysis of new benzofuranone derivatives as potential antipsychotics

…, E Ravina, CF Masaguer, J Brea, F Areias…

Index: Dezi, Cristina; Brea, Jose; Alvarado, Mario; Ravina, Enrique; Masaguer, Christian F.; Loza, Maria Isabel; Sanz, Ferran; Pastor, Manuel Journal of Medicinal Chemistry, 2007 , vol. 50, # 14 p. 3242 - 3255

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Citation Number: 21

Abstract

The complex etiology of schizophrenia has prompted researchers to develop clozapine- related multitarget strategies to combat its symptoms. Here we describe a series of new 6- aminomethylbenzofuranones in an effort to find new chemical structures with balanced affinities for 5-HT2 and dopamine receptors. Through biological and computational studies of 5-HT2A and D2 receptors, we identified the receptor serine residues S3. 36 and S5. 46 ...