A novel series of N-(azetidin-3-yl)-2-(heteroarylamino) acetamide CCR2 antagonists

…, C Crysler, C Hou, J O'Neill, D Johnson, Z Sui

Index: Subasinghe, Nalin L.; Lanter, James; Markotan, Thomas; Opas, Evan; McKenney, Sandra; Crysler, Carl; Hou, Cuifen; O'Neill, John; Johnson, Dana; Sui, Zhihua Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 4 p. 1063 - 1069

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Citation Number: 17

Abstract

The inflammatory response associated with the activation of C–C chemokine receptor CCR2 via it's interaction with the monocyte chemoattractant protein-1 (MCP-1, CCL2) has been implicated in many disease states, including rheumatoid arthritis, multiple sclerosis, atherosclerosis, asthma and neuropathic pain. Small molecule antagonists of CCR2 have been efficacious in animal models of inflammatory disease, and have been advanced into ...