Highly Enantioselective Friedel–Crafts Alkylation/N??Hemiacetalization Cascade Reaction with Indoles

…, T Wang, QQ Yang, XP Liu, Y Li, QH Deng…

Index: Cheng, Hong-Gang; Lu, Liang-Qiu; Wang, Tao; Yang, Qing-Qing; Liu, Xiao-Peng; Li, Yang; Deng, Qiao-Hui; Chen, Jia-Rong; Xiao, Wen-Jing Angewandte Chemie - International Edition, 2013 , vol. 52, # 11 p. 3250 - 3254 Angew. Chem., 2013 , vol. 125, # 11 p. 3332 - 3336,5

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Citation Number: 40

Abstract

Chiral polycyclic indoles are ubiquitous and important ring systems found in many bioactive alkaloids and pharmaceuticals.[1] As a result, extensive effort has been devoted to the development of efficient methods for their synthesis. Most approaches developed to date are based on the direct functionalization of the “privileged” indole core.[2] Representative strategies include asymmetric intramolecular alkylation of the C3, C2, or N1 positions of ...