Palladium-catalyzed one-step synthesis of isoindole-1, 3-diones by carbonylative cyclization of o-halobenzoates and primary amines

SA Worlikar, RC Larock

Index: Worlikar, Shilpa A.; Larock, Richard C. Journal of Organic Chemistry, 2008 , vol. 73, # 18 p. 7175 - 7180

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Citation Number: 51

Abstract

The palladium-catalyzed aminocarbonylation of o-halobenzoates produces 2-substituted isoindole-1, 3-diones in good yields. This methodology provides a good one-step approach to this important class of heterocycles and tolerates a variety of functional groups, including methoxy, alcohol, ketone, and nitro groups.