Enantiomeric quantifications of amino acids through their Na??Acyl amides by gas chromatography

N Hosten, MJO Anteunis

Index: Hosten, N.; Anteunis, M. J. O. Bulletin des Societes Chimiques Belges, 1988 , vol. 97, # 1 p. 45 - 47

Full Text: HTML

Citation Number: 4

Abstract

Abstract Apparent separation factors of 1.1 or higher on Chirasil Val III can be obtained for N a-acyl N-alkyl aminoacid amides allowing the use of short capillary gas chromatographic columns. A clean derivatization protocol without racemization is described, proceding through the NCA derivatives that are prepared from “in situ” silylated amino acids with trimethylsilyl cyanide.

Related Articles:

The preparation of N-carboxyanhydrides of α-amino acids using bis (trichloromethyl) carbonate

[Daly, William H.; Poche, Drew Tetrahedron Letters, 1988 , vol. 29, # 46 p. 5859 - 5862]

A new simple and quantitative synthesis of α-aminoacid-N-carboxyanhydrides (oxazolidines-2, 5-dione)

[Collet, Helene; Bied, Catherine; Mion, Louis; Taillades, Jacques; Commeyras, Auguste Tetrahedron Letters, 1996 , vol. 37, # 50 p. 9043 - 9046]

More Articles...