Chemo??enzymatic Synthesis of 6 ″??O??(3??Arylprop??2??enoyl) Derivatives of the Flavonol Glucoside Isoquercitrin

B Danieli, A Bertario, G Carrea, B Redigolo…

Index: Danieli; Bertario; Carrea; Redigolo; Secundo; Riva Helvetica Chimica Acta, 1993 , vol. 76, # 8 p. 2981 - 2991

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Citation Number: 41

Abstract

Abstract A chemo-enzymatic approach to some 6 ″-O-(3-arylprop-2-enoyl) derivatives of the flavonol glucoside isoquercitrin (2a) was explored to overcome the inability to directly introduce these acyl moieties by an enzyme-catalyzed reaction of 2a with the corresponding activated esters. This new approach was based on the regioselective introduction of a methyl malonate residue at the CH 2 OH of the sugar moiety by catalysis with the protease ...

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