Benzimidazole-substituted (3-phenoxypropyl) amines as histamine H3 receptor ligands

…, HA Vaccaro, NY Shih, JJ Piwinski, SM Williams…

Index: Aslanian, Robert; Zhu, Xiaohong; Vaccaro, Henry A.; Shih, Neng-Yang; Piwinski, John J.; Williams, Shirley M.; West Jr., Robert E. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 18 p. 5032 - 5036

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Citation Number: 13

Abstract

A series of non-imidazole histamine H3 receptor antagonists based on the (3- phenoxypropyl) amine motif, which is a common pharmacophore for H3 antagonists, has been identified. A preliminary SAR study around the amine moiety has identified 8a as a potent H3 antagonist possessing a good pharmacokinetic profile in the rat.