Design, synthesis, and structure-activity relationship of pyridyl imidazolidinones: a novel class of potent and selective human enterovirus 71 inhibitors

…, SJ Chen, KC Peng, HY Tseng, YL Chang…

Index: Shia, Kak-Shan; Li, Wen-Tai; Chang, Chung-Ming; Hsu, Ming-Chu; Chern, Jyh-Haur; Leong, Max K.; Tseng, Sung-Nien; Lee, Chung-Chi; Lee, Yen-Chun; Chen, Shu-Jen; Peng, Kuan-Chang; Tseng, Huan-Yi; Chang, Yi-Ling; Tai, Chia-Liang; Shih, Shin-Ru Journal of Medicinal Chemistry, 2002 , vol. 45, # 8 p. 1644 - 1655

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Citation Number: 100

Abstract

When skeletons of Win compounds were used as templates, computer-assisted drug design led to the identification of a novel series of imidazolidinone derivatives with significant antiviral activity against enterovirus 71 (EV 71), the infection of which had resulted in about 80 fatalities during the 1998 epidemic outbreak in Taiwan. In addition to inhibiting all the genotypes (A, B, and C) of EV 71 in the submicromolar to low micromolar range, ...