N-substituted S-2-aminoethyl thiosulfates as antiradiation agents

RD Westland, JL Holmes, ML Mouk…

Index: Westland,R.D. et al. Journal of Medicinal Chemistry, 1968 , vol. 11, p. 1190 - 1201

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Citation Number: 19

Abstract

RS iliuiilating groups. hlkylaiioii of H-2-amitloethyl thiosulfate with alkyl halides was iihed extensively,: dthorigh alkylatioiis with epoxides aiid a tosyl ester also were employed. Other pieparatioils of iriteriial Biiiito dts utilized iii thii work iiiclride oxidatioli of disiilfidea with sulfite ioti atid reactioti of N-substit rited arniiioethyl halides with thiosulfate ioti. Iiitermediateh for the alkylatioti react iotis uere prepared by v:~ i (iris cwiveiitioti: iI iiiei hodh. irirlridiiig ...