Developing potent human uric acid transporter 1 (hURAT1) inhibitors

MF Wempe, P Jutabha, B Quade, TJ Iwen…

Index: Wempe, Michael F.; Jutabha, Promsuk; Quade, Bettina; Iwen, Timothy J.; Frick, Morin M.; Ross, Ian R.; Rice, Peter J.; Anzai, Naohiko; Endou, Hitoshi Journal of Medicinal Chemistry, 2011 , vol. 54, # 8 p. 2701 - 2713

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Citation Number: 20

Abstract

The kidneys are a vital organ in the human body. They serve several purposes including homeostatic functions such as regulating extracellular fluid volume and maintaining acid− base and electrolyte balance and are essential regarding the excretion of metabolic waste. Furthermore, the kidneys play an important role in uric acid secretion/reabsorption. Abnormalities associated with kidney transporters have been associated with various ...